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Listar por autor "García Fernández, José Manuel"
Mostrando ítems 1-20 de 94
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Artículo
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
Takai, Tomoko; Higaki, Katsumi; Aguilar Moncayo, Matilde; Mena Barragán, Teresa; Hirano, Yuki; Yura, Kei; García Moreno, M. Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel; Suzuki, Yoshiyuki (Cell Press, 2013)Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
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Artículo
A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin
Mazzaglia, Antonio; Micali, Norberto; Villari, Valentina; Zagami, Roberto; Pennisi, R.M.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Sciortino, M.T.; Scolaro, L.M. (John Wiley & Sons, 2017)The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ...
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Artículo
A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells
de la Torre, Cristina; Játiva, Pablo; Posadas, Inmaculada; Manzanares, Darío; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ...
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Artículo
Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy
Cano Cano, Fátima; Alcalde Estévez, Elena; Gómez Jaramillo, Laura; Iturregui, Marta; Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen; Campos Caro, Antonio; López Tinoco, Cristina (Frontiers, 2021)Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ...
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Artículo
Antileishmanial activity of sp2-iminosugar derivatives
Sánchez Fernández, Elena Matilde; Gómez Pérez, Veronica; García Hernández, Raquel; García Fernández, José Manuel; Plata, Gabriela B.; Padrón, José M.; Ortiz Mellet, Carmen; Catanys, Santiago; Gamarro, Francisco (Royal Society of Chemistry, 2015)A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ...
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Libro
Aspectos fisiológicos de la remolacha azucarera de siembra otoñal
Echevarría Ruiz de Vargas, Cristina; Feria Bourrellier, Ana Belén; Jiménez Segovia, Eduardo Terencio; Gordo, Luis F.; Morillo-Velarde Pérez-Barquero, Rodrigo; Martínez, Juan José; García-Mauriño Ruiz-Berdejo, Sofía; Monreal Hermoso, José Antonio; Bermejo, José Luís; Caballero, Rocío; Carmona, Lourdes; Torre Casas, Ángel de la; Cires Segura, Alfonso de; Álvarez Morales, Rosario; León Morillo, María Aránzazu; Gozález, María Cruz; Cejudo Fernández, Francisco Javier; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Junta de Andalucía, Consejería de Agricultura y Pesca, 2005)Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ...
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Artículo
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
Aguilar Moncayo, Matilde; García Moreno, M. Isabel; Trapero, Ana; Egido Gabás, Meritxell; Llebaria, Amadeu; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry (Great Britain), 2011)A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
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Artículo
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
Martínez-Negro, M.; Caracciolo, G.; Palchetti, S.; Pozzi, D.; Capriotti, A.L.; Cavaliere, C.; Laganà, A; Ortiz Mellet, Carmen; Benito, Juan M.; García Fernández, José Manuel; Aicart, Emilio (Elsevier, 2017)The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ...
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Artículo
Carbohydrate supramolecular chemistry: beyond the multivalent effect
González Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2020)It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ...
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Artículo
Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose
Audemar, Maité; Atencio Genes, Loyda Esther; Ortiz Mellet, Carmen; Jérôme, F.; García Fernández, José Manuel; Oliveira Vigier, Karine De (American Chemical Society, 2017)Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ...
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Artículo
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015)The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
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Artículo
Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
García Moreno, M. Isabel; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI AG, 2008)Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
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Tesis Doctoral
Ciclodextrinas y glicomiméticos sensibles a estímulos: aplicaciones al transporte de ácidos nucleicos y a la regulación de glicosidasas
Rivero Barbarroja, Gonzalo (2024-02-09)En las últimas décadas se ha experimentado un avance notable en el diseño y preparación sistemas capaces de participar ...
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Patente. Invención
Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares
Ortiz Mellet, Carmen; Méndez Ardoy, Alejandro; Gómez García, Marta; Sevillano Trapero, Natalia; Girón González, María Dolores; Salto González, Rafael; Santoyo González, Francisco; García Fernández, José Manuel (Oficina Española de Patentes y Marcas (OEPM), 2011-09-14)Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares. La presente invención se refiere ...
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Patente
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales
García Fernández, José Manuel; Sánchez Alcázar, José Antonio; De La Mata Fernández, Mario; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2017-01-20)Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende ...
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Patente. Invención
Compuestos potenciadores de la actividad de glicosidasas mutantes
García Fernández, José Manuel; Ortiz Mellet, Carmen; García Moreno, María Isabel; Aguilar Moncayo, Matilde; Suzuki, Yoshiyuki; Ohno, Kousaku (Oficina Española de Patentes y Marcas (OEPM), 2011-01-13)Compuestos potenciadores de la actividad de glicosida sas mutantes, con actividad inhibidoras de enzimas gli cosidasas y ...
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Artículo
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
Navo, C.D.; Corzana, F.; Sánchez Fernández, Elena Matilde; Busto, J.H.; Avenoza, A.; Namba, E.; Higaki, Katsumi; Ortiz Mellet, Carmen; García Fernández, José Manuel; Peregrina, J.M. (Royal Society of Chemistry, 2016)A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ...
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Artículo
Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
Castilla, Javier; Rísquez Cuadro, Rocio; Higaki, Katsumi; Nanba, Eiji; Ohno, Kousaku; Diaz, Yolanda; Ortiz Mellet, Carmen; García Fernández, José Manuel; Castillón, Sergio (Elsevier, 2015)Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ...
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Artículo
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
García Fernández, José Manuel; Gallego Yerga, Laura; Lomazzi, Michela; Franceschi, Valentina; Sansone, Francesco; Ortiz Mellet, Carmen; Donofrio, Gaetano; Casnati, Alessandro (Royal Society of Chemistry, 2015)Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ...
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Artículo
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
Pflueger, Iris; Charrat, Coralie; Ortiz Mellet, Carmen; García Fernández, José Manuel; Di Giorgio, Christophe; Benito, Juan M. (Royal Society of Chemistry, 2016)Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...